UPDATED: JULY 2018
PUBLICATIONS
JOURNAL ARTICLES
Trevino EG, Patwardhan AN, Henry MA, Perry G, Dybdal-Hargreaves ND, Hargreaves KM, Diogenes A. Effect of irritants on the survival of human stem cells of the apical papilla in a platelet-rich plasma scaffold in human root tips. J.Enod. 37: 1109-1115; 21763903, 2011
​
Chinai JM, Taylor AB, Ryno LM, Hargreaves ND, Morris CA, Hart PJ, Urbach AR. Molecular recognition of insulin by a synthetic receptor. J Am Chem Soc. 133: 8810-8813; PMC3110995, 2011
​
Dybdal-Hargreaves NF, Holder ND, Ottoson PE, Sweeney MD, Williams T. Mephedrone: public health risk, mechanisms of action, and behavioral effects. Eur J Pharmacol. 714: 32-40; 23764466, 2013, Review
​
Gangjee A, Zaware N, Vyas Devambatla RK, Raghavan S, Westbrook CD, Dybdal-Hargreaves NF, Hamel E, Mooberry SL. Synthesis of N4-(substituted phenyl)-N4-alkyl/ desalkyl-9H-pyrimido[4,5-b]indole-2,4-diamines and identification of new microtubule disrupting compounds that are effective against multidrug resistant cells. Bioorg. Med. Chem. 21: 891-902; PMC3572549, 2013
​
Zhang X, Raghavan S, Ihnat M, Thorpe JE, Disch BC, Bastian A, Bailey-Downs LC, Dybdal-Hargreaves NF, Rohena CC, Hamel E, Mooberry SL, Gangjee A. The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents. Bioorg Med Chem. 22: 3753-3752; PMC4089508, 2014
Dybdal-Hargreaves NF, Risinger AL, Mooberry SL. Eribulin mesylate: mechanism of action of a unique microtubule targeting agent. Clin. Cancer Res. 21: 2445-2452; 25838395, 2015
​
Risinger AL*, Dybdal-Hargreaves NF*, Mooberry SL. Breast cancer cell lines exhibit differential sensitivities to microtubule targeting drugs independent of doubling time. Anticancer Res. 35: 5845-5850, 2015
​
Dasari R, De Carvalho A, Medellin DC, Middleton KN, Hague F, Volmar MN, Frolova LV, Rossato MF, De La Chapa JJ, Dybdal-Hargreaves NF, Pillai A, Kälin RE, Mathieu V, Rogelj S, Gonzales CB, Calixto JB, Evidente A, Gautier M, Munirathinam G, Glass R, Burth P, Pelly SC, van Otterlo WA, Kiss R, Kornienko A. (2015) Synthesis and biological studies of sesquiterpene polygodial: activity of 9-epipolygodial against drug-resistant cancer cells. Chem Med Chem. 10: 2015
​
Dasari R, De Carvalho A, Medellin DC, Middleton KN, Hague F, Volmar MN, Frolova LV, Rossato MF, De La Chapa JJ, Dybdal-Hargreaves NF, Pillai A, Kälin RE, Mathieu V, Rogelj S, Gonzales CB, Calixto JB, Evidente A, Gautier M, Munirathinam G, Glass R, Burth P, Pelly SC, van Otterlo WA, Kiss R, Kornienko A. Wittig derivatization of sesquiterpenoid polygodial leads to cytostatic agents with activity against drug resistant cancer cells and capable of pyrrolylation of primary amines. Eur J Med Chem. 103: 226-237, 2015
​
Rohena CC, Risinger AL, Devambatla RK, Dybdal-Hargreaves NF, Kaul R, Choudhary S, Gangjee A, Mooberry SL. Janus compounds, 5-chloro-N4-methy-N4-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, cause both microtubulue depolyumerizing and stabilizing effects. Molecules. 21: e1661, 2016
​
Gonzales CB, De La Chapa JJ, Saikumar P, Singha PK, Dybdal-Hargreaves NF, Chavez J, Horning AM, Parra J, Kirma NB. Co-targeting ALK and EGFR parallel signaling in oral squamous cell carcinoma. Oral. Oncol. 59: 12-19, 2016
Dybdal-Hargreaves NF, Risinger AL, Mooberry SL. Regulation of E-cadherin localization by microtubule targeting agents: rapid promotion of cortical E-cadherin through p130CAS/Src inhibition by eribulin Oncotarget. 9:5545-5561, 2018 [Priority (Feature) Article]
PUBLICATIONS
SELECTED ABSTRACTS
Dybdal-Hargreaves NF, Taylor AD, Hart JP, Urbach AR.; March 2010; American Chemical Society Biannual Meeting; San Francisco, CA; Crystal structure of an insulin-cucurbitu[7]uril complex. (Poster)
Dybdal-Hargreaves NF and Mooberry SL.; Oct. 25th 2013; 20th Annual Graduate Student Symposium; San Antonio, TX; Microtubule Targeting Agents Disrupt BCAR1 Localization and BCAR1 Associated Signaling in Cancer Cells (Poster)
Dybdal-Hargreaves NF and Mooberry SL.; May 3rd 2013; 5th Annual Terry M. Mikiten, Ph.D., Graduate Student Research Forum and Lecture; San Antonio, TX; The case for non-mitotic effects of microtubule targeting agents contributing to anticancer efficacy in the clinic (Poster)
Dybdal-Hargreaves NF and Mooberry SL.; April 10th 2013; UTHSCSA Dental Science Symposium; San Antonio, TX; The case for non-mitotic effects of microtubule targeting agents contributing to anticancer efficacy in the clinic (Poster)
Dybdal-Hargreaves NF and Mooberry SL.; February 2014; Keystone Symposium: Cillia, Development and Human Disease; Lake Tahoe, CA; Differential effects of microtubule targeting agents on primary cilia in triple negative breast cancer cells. (Poster)
Dybdal-Hargreaves NF and Mooberry SL.; March 2014; 32nd Annual UTHSCSA Dental Science Symposium; San Antonio, TX; Differential effects of microtubule targeting agents on primary cilia in triple negative breast cancer cells. (Poster)
Dybdal-Hargreaves NF and Mooberry SL.; May 2014; 6th Annual Terry M. Mikiten, Ph.D., Graduate Student Research Forum and Lecture; San Antonio, TX; Differential effects of microtubule targeting agents on primary cilia in triple negative breast cancer cells. (Poster)
Dybdal-Hargreaves NF and Mooberry SL.; October 2014; 21st Annual Graduate Student Symposium; San Antonio, TX; Differential sensitivity of oral squamous cell carcinoma cell lines to anticancer agents suggests molecular subtypes in the disease. (Poster, Won Outstanding [Best] Poster Award)
Risinger AL, Dybdal-Hargreaves NF, Mooberry SL.; December 2014; American Society for Cell Biology Annual Meeting (ASCB); Philadephia, PA; Differential sensitivity of breast cancer cell lines to diverse microtubule targeting agents. (Poster)
​
Dybdal-Hargreaves NF, Rohena CC, Risinger AL, and Mooberry SL. March 14th 2015. NIDCR Trainee Symposium at the Annual Meeting of the American Associations for Dental Research (AADR). Boston, MA. OSCC lines represent multiple molecular subtypes with different drug sensitivities. (Poster)
Dybdal-Hargreaves NF, Rohena CC, Risinger AL, and Mooberry SL. March 2015. 33rd Annual UTHSCSA Dental Science Symposium. San Antonio, TX. Differential sensitivity of oral squamous cell carcinoma cell lines to anticancer agents suggests molecular subtypes in the disease. (Poster, Winner of the Post-Doctoral Division Poster Award)
Dybdal-Hargreaves NF, Risinger AL, and Mooberry SL. April 18th 2015. Annual Meeting of the American Association for Cancer Research (AACR). Philadelphia, PA. Microtubule targeting agents differentially disrupt scaffold proteins involved in the sensitivity of breast cancer cells to these agents. (Poster)
Dybdal-Hargreaves NF, Rohena CC, Risinger AL, and Mooberry SL. December 2015. Annual San Antonio Breast Cancer Symposium (SABCS). San Antonio, TX. Eribulin affects E-cadherin localization consistent with a reversal of the epithelial-to-mesenchymal transition. (Poster)
Dybdal-Hargreaves NF, Rohena CC, Risinger AL, and Mooberry SL. March 9th 2016. 34th Annual UTHSCSA Dental Science Symposium. San Antonio, TX. Eribulin affects E-cadherin localization consistent with a reversal of the epithelial-to-mesenchymal transition. (Poster, Frank DeHotes Oral and Maxillofacial Surgery Travel Award and 2ndPlace Winner of the Post-Doctoral Division Poster Award)
Dybdal-Hargreaves NF Rohena CC, Risinger AL, and Mooberry SL. March 16th 2016; NIDCR Trainee Symposium at the Annual Meeting of the American Associations for Dental Research (AADR). Los Angeles, CA. Eribulin affects E-cadherin localization consistent with a reversal of the epithelial-to-mesenchymal transition. (Poster)
Dybdal-Hargreaves NF Rohena CC, Risinger AL, and Mooberry SL. October 28th 2016; 23rdAnnual Graduate School Symposium. San Antonio TX. Eribulin affects E-cadherin localization consistent with a reversal of the epithelial-to-mesenchymal transition. (Poster)
Dybdal-Hargreaves NF and Mooberry SL. March 15th 2017. 35th Annual UTHSCSA Dental Science Symposium. San Antonio, TX. Effects of docetaxel on notch receptors in oral cancer cell lines. (Poster, 1stPlace Winner of the Post-Doctoral Division Poster Award)
Dybdal-Hargreaves NF and Mooberry SL. March 24th 2017. NIDCR Trainee Symposium at the Annual Meeting of the American Associatinos for Dental Research (AADR). San Francisco CA. Effects of docetaxel on notch receptors in oral cancer cell lines. (Poster)
Dybdal-Hargreaves NF and Mooberry SL. March 14th 2018. 36th Annual UTHSCSA Dental Science Syposium. San Antonio, TX. Microtubule targeting agents disrupt notch signaling in oral cancer. (poster)
ORAL PRESENTATIONS
PRESENTATIONS
AUGUST 2009
"Structural Studies of Insulin-Cucurbit[7]uril Interactions."
Trinity Summer Research Symposium. Trinity University; San Antonio, Texas
​
JULY 2011
"Microtubule Targeting Agents."
Pharm-SURF Summer Research Symposium, UTHSCSA; San Antonio, Texas
​
AUGUST 2013
"Novel Mechanisms of Microtubule Targeting Agents."
Pharmacology Department Summer Research Practicmum, UTHSCSA; San Antonio, Texas
​
NOVEMBER 2013
"Enhanced Inhibition of ERK Signaling by a Novel Allosteric MEK Inhibitor,
CH5126766, That Suppresses Feedback Reactivation of RAF Activity."
Pharmacology Journal Club, UTHSCSA; San Antonio, Texas
​
FEBRUARY 2015
"Drugging MYCN through an Allosteric Transition in Aurora Kinase A."
Pharmacology Journal Club, UTHSCSA; San Antonio, Texas
​
JUNE 2015
"Novel Mechanisms of Microtubule Targeting Agents."
Dissertation Proposal, UTHSCSA; San Antonio, Texas
​
JUNE 2016
"Microtubule Targeting Agents Differentially Interrupt
Scaffold Mediated Signaling"
NIDCR COSTAR Site Visit; San Antonio, Texas
​
DECEMBER 2016
"Thyroid Issues and Dentistry"
Teaching Honors Seminar, UTHSCSA; San Antonio, Texas
​
SELECTED POSTER PRESENTATIONS
PRESENTATIONS
MARCH 2010
Dybdal-Hargreaves NF, Taylor AD, Hart JP, and Urbach AR. March 2010. American Chemical Society Biannual Meeting (ACS). San Francisco, CA. Crystal structure of an insulin- cucurbitu[7]uril complex. (Poster)
​
OCTOBER 2013
Dybdal-Hargreaves NF and Mooberry SL. Oct. 25th 2013. 20th Annual Graduate Student Symposium. San Antonio, TX. Microtubule Targeting Agents Disrupt BCAR1 Localization and BCAR1 Associated Signaling in Cancer Cells. (Poster)
​
FEBRUARY 2014
Dybdal-Hargreaves NF and Mooberry SL. February 2014. Keystone Symposium: Cillia, Development and Human Disease. Lake Tahoe, CA. Differential effects of microtubule targeting agents on primary cilia in triple negative breast cancer cells. (Poster)
​
OCTOBER 2014
[ AWARDED - Outstanding (Best) Poster Award ]
Dybdal-Hargreaves NF and Mooberry SL. October 2014. 21st Annual Graduate Student Symposium. San Antonio, TX. Differential sensitivity of oral squamous cell carcinoma cell lines to anticancer agents suggests molecular subtypes in the disease.
​
DECEMBER 2014
Risinger AL, Dybdal-Hargreaves NF, and Mooberry SL. December 2014. American Society for Cell Biology Annual Meeting (ASCB). Philadelphia, PA. Differential sensitivity of breast cancer cell lines to diverse microtubule targeting agents. (Poster)
​
MARCH 2015
Dybdal-Hargreaves NF, Rohena CC, Risinger AL, and Mooberry SL. March 14th 2015. NIDCR Trainee Symposium at the Annual Meeting of the American Associations for Dental Research (AADR). Boston, MA. OSCC lines represent multiple molecular subtypes with different drug sensitivities. (Poster)
​
MARCH 2015
[ AWARDED - 1st Place -Post-Doctoral Division Poster Award ]
Dybdal-Hargreaves NF, Rohena CC, Risinger AL, and Mooberry SL. March 2015. 33rd Annual UTHSCSA Dental Science Symposium. San Antonio, TX. Differential sensitivity of oral squamous cell carcinoma cell lines to anticancer agents suggests molecular subtypes in the disease.
​
APRIL 2015
Dybdal-Hargreaves NF, Risinger AL, and Mooberry SL. April 18th 2015. Annual Meeting of the American Association for Cancer Research (AACR). Philadelphia, PA. Microtubule targeting agents differentially disrupt scaffold proteins involved in the sensitivity of breast cancer cells to these agents. (Poster)
​
DECEMBER 2015
Dybdal-Hargreaves NF, Rohena CC, Risinger AL, and Mooberry SL. December 2015. Annual San Antonio Breast Cancer Symposium (SABCS). San Antonio, TX. Eribulin affects E-cadherin localization consistent with a reversal of the epithelial-to-mesenchymal transition. (Poster)
​
MARCH 2016
[ AWARDED - Frank DeHotes Oral and Maxillofacial Surgery Travel Award ]
[ AWARDED - 2nd Place - Post-Doctoral Division Poster Award ]
Dybdal-Hargreaves NF, Rohena CC, Risinger AL, and Mooberry SL. March 9th 2016. 34thAnnual UTHSCSA Dental Science Symposium. San Antonio, TX. Eribulin affects E-cadherin localization consistent with a reversal of the epithelial-to-mesenchymal transition. (Poster, Frank DeHotes Oral and Maxillofacial Surgery Travel Award and 2nd Place Winner of the Post- Doctoral Division Poster Award)
​
MARCH 2016
Dybdal-Hargreaves NF, Rohena CC, Risinger AL, and Mooberry SL. March 16th 2016; NIDCR Trainee Symposium at the Annual Meeting of the American Associations for Dental Research (AADR). Los Angeles, CA. Eribulin affects E-cadherin localization consistent with a reversal of the epithelial-to-mesenchymal transition. (Poster)
​
MARCH 2017
[ AWARDED - 1st Place -Post-Doctoral Division Poster Award ]
Dybdal-Hargreaves NF and Mooberry SL. March 15th 2017. 35th Annual UTHSCSA Dental Science Symposium. San Antonio, TX. Effects of docetaxel on notch receptors in oral cancer cell lines. (Poster, 1st Place Winner of the Post-Doctoral Division Poster Award)
MARCH 2018
Dybdal-Hargreaves NF and Mooberry SL. March 24th 2017. NIDCR Trainee Symposium at the Annual Meeting of the American Associatinos for Dental Research (AADR). San Francisco CA. Effects of docetaxel on notch receptors in oral cancer cell lines. (Poster)